Cassandra, Schmerz, ache, aches and pains, aching heart, adversity, affliction, agony, agony of mind, angst, anguish, anxiety, bale, bitterness, bleeding heart, broken heart, burden, calamity, care, carking care, catastrophe, cheerlessness, crushing, curse, cynic, dampener, damper, dejection, depression, depth of misery, desolation, despair, desperation, despondency, destitution, disaster, discomfort, discontent, displeasure, distress, dolor, extremity, gloom, gloomy Gus, grief, grimness, grouch, grump, hardship, heartache, heartfelt grief, heartgrief, heavy heart, humorlessness, hurt, hurting, indigence, infelicity, infestivity, joylessness, killjoy, lamentation, languishment, malaise, malcontent, melancholia, melancholy, mirthlessness, misfortune, ordeal, pain, pang, passion, penury, pessimist, pining, poverty, privation, prophet of doom, prostration, sadness, sordidness, sorrow, sorrowing, sourpuss, spoilsport, squalor, stitch, suffering, suicidal despair, throe, trial, tribulation, trouble, twinge, uncheerfulness, unhappiness, unjoyfulness, unmirthfulness, wet blanket, woe, wretchedness