adverse circumstances, adversity, affliction, aggravation, agitation, algesia, amplification, animation, annoyance, arousal, arousing, augmentation, blight, bummer, care, chafe, contentiousness, cross, curse, deepening, deliberate aggravation, deterioration, difficulties, difficulty, disapprobation, disapproval, discontent, displeasure, dissatisfaction, downer, electrification, embittering, embitterment, enhancement, enlargement, exacerbation, exasperation, excitation, excitement, exhilaration, festering, firing, fomentation, fret, gall, galvanization, hard knocks, hard life, hard lot, hardcase, hardship, heightening, incitation, incitement, increase, inflammation, infuriation, instigation, intensification, irritant, lathering up, magnification, pep rally, pep talk, perturbation, plight, predicament, pressure, provocation, rabble-rousing, rankling, resentfulness, resentment, rigor, sea of troubles, sensitiveness, sharpening, sore, sore spot, soreness, souring, steaming up, stimulation, stimulus, stirring-up, stirring, stirring up, stress, stress of life, tenderness, trial, tribulation, trouble, troubles, vale of tears, vexation, vicissitude, whipping up, working up, worsening