Gordian knot, abstruseness, adverse circumstances, adversity, affliction, aggravation, agreement to disagree, altercation, annoyance, arduousness, asperity, bad news, bedevilment, beef, bickering, blight, block, blockade, bore, bother, botheration, bothersomeness, bottleneck, bummer, burden, burthen, care, cargo, catch, challenge, charge, complexity, complication, controversy, cordon, crabbedness, crampedness, crashing bore, cross-purposes, cross, cumbrance, curse, curtain, deadweight, deepness, demurral, demurrer, determent, deterrent, devilment, difference, difference of opinion, difficulties, dilemma, disadvantage, disagreement, disparity, dispute, distress, dividedness, division, dogging, downer, drag, drawback, embarrassment, emergency, encumbrance, esoterica, exasperation, exigency, falling-out, fight, fix, formidableness, freight, hamper, handicap, hang-up, harassment, hard knocks, hard life, hard lot, hardcase, hardness, hardship, harrying, hassle, hazard, headache, heavy sledding, hindrance, hitch, hot water, hounding, hurdle, impediment, impedimenta, imposition, inconvenience, intricacy, irritation, jam, joker, knottiness, laboriousness, load, lumber, mess, misunderstanding, molestation, nuisance, objection, obstacle, obstruction, obstructive, odds, one small difficulty, onus, pack, painfulness, pass, penalty, persecution, pest, pickle, pinch, pitfall, plight, polarization, predicament, pressure, problem, profoundness, profundity, protest, quandary, question, reconditeness, remonstrance, remonstration, rigor, rub, scrape, sea of troubles, snag, squabble, strain, strait, straits, stress, stress of life, stumbling block, stumbling stone, trial, tribulation, trouble, troubles, vale of tears, variance, vexation, vexatiousness, vicissitude, vigor, weight, white elephant, worriment, worry