Herculean, adverse, aggravating, alarming, annoying, antagonistic, arduous, awkward, backbreaking, besetting, bothering, bothersome, burdensome, chafing, choking, clumsy, conflicting, constrictive, contrary, counter, counteractive, counterproductive, crosswise, crushing, detrimental, difficult, discommodious, disquieting, distressful, distressing, disturbing, effortful, exasperating, forced, fretting, galling, grueling, harassing, hard-earned, hard-fought, hard, harmful, heavy, hefty, hindering, hindersome, hostile, importunate, importune, in opposition, in the way, incommodious, inconvenient, infestive, inhibiting, inhibitive, inimical, interrupting, interruptive, irking, irksome, irritating, killing, labored, laborious, mean, miserable, not easy, obstructing, obstructive, obstruent, occlusive, onerous, operose, opposed, opposing, opposite, oppressive, painful, pesky, pestering, pestiferous, pestilent, pestilential, plaguesome, plaguey, plaguing, provoking, punishing, repressive, restrictive, rigorous, sinister, stifling, strained, strangling, strenuous, stressful, suppressive, teasing, tiresome, toilsome, tormenting, tough, troubling, troublous, trying, ugly, unfavorable, unhandy, untoward, unwieldy, uphill, upsetting, vexatious, vexing, wearisome, wicked, worrisome, worrying, wretched