acerb, acerbate, acerbic, acid, acidic, acidulent, acidulous, acrimonious, adrenal, bearish, bitchy, bitter, blase, burning, cankered, cantankerous, caustic, choleric, churlish, crabbed, cranky, cross-grained, cross, crusty, cussed, disagreeable, dispirited, eccrine, embittered, endocrine, excitable, exocrine, fed-up, feisty, fractious, glandular, glandulous, gonadal, good and tired, holocrine, huffish, huffy, humoral, irascible, irked, irritable, jaded, life-weary, luteal, mean, melancholic, melancholy, merocrine, ornery, ovarian, pancreatic, perverse, prostatic, rancorous, rankled, resentful, resenting, satiated, sick, sick of, snappish, sore, spiteful, spleeny, stewing, testy, thymic, thyroidal, tired, tired of, tired of living, tired to death, ugly, virulent, waspish, wearied, weariful, weary, weary unto death, world-weary