acerbity, acridity, acridness, affliction, astringence, astringency, bitter cup, bitter draft, bitter draught, bitterness, burden, burden of care, cankerworm of care, care, causticity, cross, crown of thorns, curse, distress, encumbrance, gall, gall and wormwood, grievance, infliction, load, oppression, pack of troubles, peck of troubles, pungency, sea of troubles, sharpness, sorrow, sourness, tartness, thorn, trouble, waters of bitterness, weight, woe

Amytal, Amytal pill, Demerol, Dolophine, H, Luminal, Luminal pill, M, Mickey Finn, Nembutal, Nembutal pill, Seconal, Seconal pill, Tuinal, Tuinal pill, alcohol, amobarbital sodium, analgesic, anesthetic, anodyne, barb, barbiturate, barbiturate pill, black stuff, blue, blue angel, blue devil, blue heaven, blue velvet, calmative, chloral hydrate, codeine, codeine cough syrup, depressant, depressor, dolly, dope, downer, drug, goofball, hard stuff, heroin, hop, horse, hypnotic, junk, knockout drop, knockout drops, laudanum, liquor, lotus, meperidine, methadone, morphia, morphine, narcotic, opiate, opium, pacifier, pain-killer, pain killer, paregoric, pen yan, phenobarbital, phenobarbital sodium, purple heart, quietener, rainbow, red, scag, secobarbital sodium, sedative, shit, sleep-inducer, sleeper, sleeping draught, smack, sodium thiopental, somnifacient, soother, soothing syrup, soporific, tar, tranquilizer, turps, white stuff, yellow, yellow jacket