acute, affecting, afflictive, agonizing, annoying, atrocious, baleful, baneful, biting, bitter, bleak, bothersome, calamitous, chafing, cheerless, comfortless, corroding, corrosive, corrupting, corruptive, counterproductive, cramping, cruel, damaging, deadly, deleterious, deplorable, depressing, depressive, detrimental, dire, disadvantageous, discomforting, dismal, dismaying, disquieting, disserviceable, distressful, disturbing, dolorific, dolorogenic, dolorous, dreary, excruciating, fretting, gnawing, grave, grievous, griping, harassing, hard, harmful, harrowing, harsh, heartbreaking, hurtful, hurting, injurious, joyless, lamentable, lethal, malefic, malevolent, malign, malignant, mischievous, mournful, moving, noisome, noxious, ominous, painful, paroxysmal, pathetic, pernicious, piercing, piteous, pitiable, plaguing, poignant, poisonous, prejudicial, pungent, racking, regrettable, rueful, sad, saddening, scatheful, severe, sharp, shooting, sore, sorrowful, spasmatic, spasmic, spasmodic, stabbing, stinging, tormenting, torturous, touching, toxic, troublesome, uncomfortable, unfortunate, upsetting, venenate, veneniferous, venenous, venomous, vicious, virulent, woebegone, woeful, worrisome, worrying, wretched