ado, adverse circumstances, adversity, affliction, aggravation, amplification, anger, annoyingness, anxiety, augmentation, aversion, bad news, bedevilment, besetment, blight, bore, bother, botheration, bothering, bothersomeness, bummer, can of worms, care, contentiousness, crashing bore, cross, curse, deepening, deliberate aggravation, deterioration, devilment, difficulties, difficulty, disadvantage, disapprobation, disapproval, discontent, disgust, dislike, displeasure, dissatisfaction, distaste, distress, dogging, downer, drag, embittering, embitterment, enhancement, enlargement, evil, exacerbation, exasperation, great ado, harassment, hard knocks, hard life, hard lot, hardcase, hardship, harrying, headache, heightening, hounding, inconvenience, increase, indignation, intensification, ire, irking, irksomeness, irritant, irritation, magnification, matter, molestation, nuisance, pain, peck of troubles, persecution, peskiness, pest, pester, pestering, pestiferousness, pique, plague, plaguesomeness, plight, pother, predicament, pressure, problem, provocation, provoking, provokingness, repugnance, repulsion, resentfulness, resentment, revulsion, riding, rigor, sea of troubles, sharpening, souring, stress, stress of life, teasing, tiresomeness, trial, tribulation, trouble, troubles, troublesomeness, vale of tears, vexation, vexatiousness, vexing, vicissitude, wearisomeness, worriment, worrisomeness, worry, worsening, wrath